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The Biology of Aging and Frailty

Reflect on the concepts of aging as presented in these documents and videos. What things surprised you? Write a short paragraph summarizing what new ideas or concepts you learned from this, or anything that you previously though differently about.
links attached
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052959/
http://www.who.int/ageing/en/

8 questions 200 words long each.

1. Several biology students have just returned from a field trip in which they were asked to collect prokaryotes and eukaryotes. The eukaryotic organisms were to be divided into plant cells, animal cells, or “other.” The students have access to a light and electron microscope. Can you suggest how they could determine whether these cells are prokaryotic or eukaryotic? How could they distinguish plant from animal cells? 2. Discuss how ER stress responses contribute to the pathology of chronic inflammatory diseases such as diabetes and atherosclerosis. 3. Discuss the evidence supporting an evolutionary connection between the neuroendocrine system and the UPR to modulate behavioral adaptive responses. 4. Discuss the link between type I IFNs and ER stress in the various pathological contexts. 5. Discuss the mitochondria-ER signaling and activity in neurodegenerative diseases. 6. Discuss the relationship between SR/ER dysfunction and diseases. 7. Discuss the major functions of endoplasmic reticulum (ER). 8. Overall, endoplasmic reticulum (ER) stress and autophagy play critical roles in various CNS cells in both health and various neurodegenerative diseases. In view of this, the development of brain penetrating small molecules that can function as ROS scavengers, ER stress inhibitors, autophagy modulators, and anti-inflammatory molecules, and that can impact the ER stress and/or autophagy signaling pathways could thus be considered as potential therapeutic strategies for restoring cognitive deficits associated with neurodegenerative disorders. interview a person who is your relative, colleague, friend or family member to obtain comments on the possible pharmacological interventions for restoring cognitive deficits associated with neurodegenerative disorders. Please feel free to make a background introduction to the interviewee if necessary

Biology Question

Biology Assignment Help It is just 7 questions to do you will find them down in the pictures.
Important
When answering questions in a mathematics course always be sure to use the following guidelines to help you do your best:
This assignment contains 7 questions..
Provide full solutions, showing all of your steps.
Include only one step or idea per line.
Use one equal sign per line.
Line up equal signs vertically.
Don’t use self-developed short form notations.

Lab : about fossil hominins based on the analysis of qualitative and quantitative empirical data

The purpose of this lab is for you to infer appropriate conclusions about fossil hominins based on the analysis of qualitative and quantitative empirical data and identify key physical (morphological), physiological (functional), and behavioral traits in human fossil ancestors.
you become familiar with the following important content knowledge in anthropology:
later Homo and Homo sapiens evolution
hypotheses to explain the origins of modern humans
infer specific behaviors based on anatomical traits
identify anatomical similarities and differences in the later members of the genus Homo
identify anatomical traits used to identify modern Homo sapiens in the paleoanthropological record
Print the Lab 12 worksheet and write-in your answers OR open the lab in Adobe (or whatever pdf. reader you use) and type-in your answers using the text-box function
Step 2: Open the Lab 12 workstations.
Kabwe, Zambia (Africa), ~275-325 kya
Homo heidlebergensis by Geospatial and Virtual Archaeology Lab and Studio on Sketchfab
Steinheim, Germany, 250-350 kya

Homo heidelbergensis (Steinheim skull)(1979rp45) by RLA Archaeology on Sketchfab

Florisbad, Orange Free State, South Africa, 250-350 kya

Homo heidelbergensis (Florisbad) (1979rp24) by RLA Archaeology on Sketchfab





Workstation 2: The NeanderthalsInstructions:
Observe the 3D models of the Neanderthals below.
Compare and contrast the two crania. How are they similar? How are they different? Record your response on the Lab 12 worksheet.
Identify three observable traits that are present on both crania that are derived traits in Neanderthals. Record your response on the Lab 12 worksheet.
La Chapelle-aux-Saints, France, 47-56 kya
(433rp7) by RLA Archaeology on Sketchfab
Gibraltar 1, ~35 kya, found in Forbes Quarry, Gibraltar (one of the youngest Neanderthal fossils, ~35 kya is super recent!!)
Gibraltar 1 Skull with Texture by Wellesley College on Sketchfab
Workstation 3: Neanderthals vs. Modern Homo sapiensInstructions:
Observe the 3D models of mandibles from a Neanderthal and a modern Homo sapiens below.
Compare and contrast the two samples. How are they similar? How are they different? Record your response on the Lab 12 worksheet.
Identify one observable trait that is present on the Neanderthal mandible, but not present on the modern Homo sapiens mandible. Record your response on the Lab 12 worksheet.
Identify one observable trait that is present on the modern Homo sapiens mandible, but not present on the Neanderthal mandible. Record your response on the Lab 12 worksheet.
Spy Cave, Namur, Belgium, ~40 kya (Neanderthal)

(Spy 2) Mandible (433rp20) by RLA Archaeology on Sketchfab

Hotu Cave, Iran, ~9,900 – 7,200 years before present (modern Homo sapiens)

Homo sapiens (Hotu Cave) (1979rp28) – mandible by RLA Archaeology on Sketchfab
Workstation 4: Evolution of Homo sapiensAs with other transitions in hominin evolution, modern traits do not appear fully formed or all at once. The traits common to modern Homo sapiens appeared in a mosaic manner. In this workstation, you will look at how our skull anatomy has changed over time and you will also observe geographic variation in our species.
Instructions:
Observe the 3D models of modern Homo sapiens below. (Some of the models are a little dark. Just do the best you can.)
Describe how the cranial morphology in modern Homo sapiens has evolved (changed) over time based on your observations of the samples below. Record your response on the Lab 12 worksheet.
Identify one observable derived modern Homo sapiens trait that all the crania share. Record your response on the Lab 12 worksheet.
Which hypothesis to explain the origins of modern Homo sapiens is best supported by the morphology of these crania (Multiregional or Out of Africa)? Please be cognizant of the times and geographical areas represented by the samples. Please explain your answer and any limitations associated with the data (aside from the small sample size). Record your response on the Lab 12 worksheet.
Herto: Middle Awash, Ethiopia, ~160 kya
Homo sapiens Cranium by UCFanthropology on Sketchfab
Skhul 5 sample: Mugharet es-Skhul, Wadi el-Mughara, Israel, 80-120 kya

Homo sapiens Skhul 5 (2501.1rp37-1) by RLA Archaeology on Sketchfab
Wajak, East Java, Indonesia, ~28-38 kya

Homo sapiens (Wadjak 1) (1979rp11) by RLA Archaeology on Sketchfab
Cro-Magnon, Les Eyzies, Dordogne, France ~ 27 kya

Homo sapiens (Cro-Magnon I) Skull (1979rp16-1) by RLA Archaeology on Sketchfab
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